Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2401265 | 0.91 | KDM4E (0.53) | KDM4EHSD17B10L3MBTL1GAAPCSK9 | |
| SCHEMBL2400764 | 0.84 | CNR1 (0.45) | L3MBTL1GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6848470 | 0.84 | KDM4E (0.34) | KDM4EHSD17B10L3MBTL1GAAPCSK9 | |
| SCHEMBL2399309 | 0.79 | KMT2A (0.47) | L3MBTL1GAAKMT2AMAPTHTT | |
| SCHEMBL6412521 | 0.78 | EPHX2 (0.47) | KDM4EHSD17B10L3MBTL1GAASMN1; SMN2 | |
| SCHEMBL6411431 | 0.76 | HTT (0.51) | KDM4EL3MBTL1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL2402766 | 0.76 | HTT (0.42) | HSD17B10L3MBTL1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL2403572 | 0.76 | KMT2A (0.41) | L3MBTL1GAAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6410853 | 0.75 | SMN1; SMN2 (0.41) | KDM4EHSD17B10GAAKMT2ASMN1; SMN2 | |
| SCHEMBL2400775 | 0.75 | CACNA1B (0.43) | L3MBTL1GAAKMT2ASMN1; SMN2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |