Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2401597 | 0.82 | KDM4E (0.51) | GAACACNA1BHSD11B1L3MBTL1LMNA | |
| SCHEMBL6411431 | 0.78 | HTT (0.51) | GAACACNA1BHSD11B1L3MBTL1LMNA | |
| SCHEMBL2401334 | 0.78 | CNR1 (0.51) | GAACACNA1BLMNACNR1 | |
| SCHEMBL2405120 | 0.77 | GAA (0.47) | GAACACNA1BL3MBTL1LMNACNR1 | |
| SCHEMBL2400790 | 0.77 | GAA (0.51) | GAACACNA1BL3MBTL1LMNAHTT | |
| SCHEMBL2403271 | 0.76 | GAA (0.50) | GAACACNA1BLMNAHTTCNR1 | |
| SCHEMBL6411436 | 0.73 | GAA (0.50) | GAACACNA1BHSD11B1L3MBTL1LMNA | |
| SCHEMBL2401265 | 0.71 | KDM4E (0.53) | GAAPOLBL3MBTL1LMNAHTT | |
| SCHEMBL2399309 | 0.71 | KMT2A (0.47) | GAAL3MBTL1LMNAHTTCNR1 | |
| SCHEMBL2400764 | 0.71 | CNR1 (0.45) | GAACACNA1BL3MBTL1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |