Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6412725 | 0.84 | NAMPT (0.44) | NAMPTTBXAS1CHRNA7IRAK4EPHX2 | |
| SCHEMBL6417110 | 0.84 | CHRNA7 (0.44) | NAMPTCHRNA7 | |
| SCHEMBL6411827 | 0.82 | CHRNA7 (0.30) | NAMPTCHRNA7IRAK4 | |
| SCHEMBL6411848 | 0.80 | NAMPT (0.41) | NAMPTHDAC1ESR1TBXAS1CHRNA7 | |
| SCHEMBL6416960 | 0.80 | NAMPT (0.41) | NAMPTHDAC1ESR1TBXAS1CHRNA7 | |
| SCHEMBL6415882 | 0.80 | CHRNA7 (0.40) | CHRNA7IRAK4HPGDS | |
| SCHEMBL6418263 | 0.80 | CHRNA7 (0.49) | CHRNA7IRAK4 | |
| SCHEMBL6413063 | 0.80 | CHRNA7 (0.41) | CHRNA7 | |
| SCHEMBL6414394 | 0.79 | NAMPT (0.50) | NAMPT | |
| SCHEMBL6417875 | 0.78 | CHRNA7 (0.41) | NAMPTTBXAS1CHRNA7IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236264-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | claimed |
| US-20050215584-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | PFIZER INC | 2005-09-29 | — | — | US | disclosed |
| US-6858613-B2 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | PFIZER INC. (US) | 2005-02-22 | — | — | US | disclosed |
| US-20030236264-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236264-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | NAT1, CYP11B1, COASY | NAMPT 353/4885HDAC1 29/4885ESR1 1872/4885 |
| US-20050215584-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | CHRNA7, UGT2B7, CHRNA5 | NAMPT 873/4885HDAC1 91/4885ESR1 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.