Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 9/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 9/20 | 0.34 |
| ▸ | MEN1 | O00255 | 8/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6414910 | 1.00 | CYP3A4 (0.38) | CYP3A4CYP1A2CYP2D6ESR1ESR2 | |
| SCHEMBL6417241 | 0.89 | SMN1; SMN2 (0.43) | ESR1ESR2MAPTTP53SMN1; SMN2 | |
| SCHEMBL6417228 | 0.89 | SMN1; SMN2 (0.43) | ESR1ESR2MAPTTP53SMN1; SMN2 | |
| SCHEMBL6419807 | 0.89 | TP53 (0.40) | ESR1ESR2PIM1MAPTTP53 | |
| SCHEMBL6431548 | 0.89 | AKR1C3 (0.38) | CYP3A4CYP1A2CYP2D6MAPTSMN1; SMN2 | |
| SCHEMBL6431540 | 0.89 | AKR1C3 (0.38) | CYP3A4CYP1A2CYP2D6MAPTSMN1; SMN2 | |
| SCHEMBL6419800 | 0.89 | TP53 (0.40) | ESR1ESR2PIM1MAPTTP53 | |
| SCHEMBL6432637 | 0.89 | TP53 (0.35) | PIM1MAPTTP53SMN1; SMN2POLB | |
| SCHEMBL6432628 | 0.89 | TP53 (0.35) | PIM1MAPTTP53SMN1; SMN2POLB | |
| SCHEMBL6416484 | 0.85 | MAPT (0.36) | ESR1ESR2MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143382-A1 | Heterocyclic compounds as pharmaceutically active compounds | 4SC AG (DE) | 2005-06-30 | — | — | US | disclosed |
| EP-1529531-A1 | Oxadiazolopyrazine derivatives as pharmaceutically active compounds | 4SC AG (DE) | 2005-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143382-A1 | Heterocyclic compounds as pharmaceutically active compounds | NR5A2, NR1H2, NR2C2 | CYP3A4 52/4885CYP1A2 65/4885CYP2D6 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.