⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349456 | 0.94 | CYP2D6 (0.46) | — | |
| SCHEMBL7294980 | 0.80 | HRH3 (0.42) | — | |
| SCHEMBL13552291 | 0.78 | — | — | |
| SCHEMBL398826 | 0.78 | — | — | |
| SCHEMBL13961615 | 0.78 | CYP2D6 (0.43) | — | |
| SCHEMBL349705 | 0.77 | — | — | |
| SCHEMBL6781145 | 0.75 | — | — | |
| SCHEMBL197630 | 0.75 | — | — | |
| SCHEMBL20633400 | 0.74 | CYP2D6 (0.40) | — | |
| SCHEMBL5539780 | 0.72 | CXCR4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030083230-A1 | Reversal of multidrug resistance in human colon carcinoma cells | AMERICAN CYANAMID COMPANY | 2003-05-01 | — | — | US | claimed |
| US-20020169111-A1 | Reversal of multidrug resistance in human colon carcinoma cells | AMERICAN CYANAMID COMANY (US) | 2002-11-14 | — | — | US | claimed |
| US-20020156015-A1 | Reversal of multidrug resistance in human colon carcinoma cells | AMERICAN CYANAMID COMPANY | 2002-10-24 | — | — | US | claimed |
| US-6372775-B1 | ANTICANCER AGENT | AMERICAN CYANAMID COMPANY | 2002-04-16 | — | — | US | claimed |
| US-5856556-A | Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics | SANKYO COMPANY, LIMITED (JP) | 1999-01-05 | — | — | US | claimed |
| US-6878737-B2 | Reversal of multidrug resistance in human colon carcinoma cells | WYETH HOLDINGS CORPORATION (US) | 2005-04-12 | — | — | US | disclosed |
| US-20030083230-A1 | Reversal of multidrug resistance in human colon carcinoma cells | AMERICAN CYANAMID COMPANY | 2003-05-01 | — | — | US | disclosed |
| US-6537964-B1 | The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs. | WYETH HOLDINGS CORPORATION | 2003-03-25 | — | — | US | disclosed |
| US-20020169111-A1 | Reversal of multidrug resistance in human colon carcinoma cells | AMERICAN CYANAMID COMANY (US) | 2002-11-14 | — | — | US | disclosed |
| US-20020156015-A1 | Reversal of multidrug resistance in human colon carcinoma cells | AMERICAN CYANAMID COMPANY | 2002-10-24 | — | — | US | disclosed |
| US-6372775-B1 | ANTICANCER AGENT | AMERICAN CYANAMID COMPANY | 2002-04-16 | — | — | US | disclosed |
| US-5856556-A | Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics | SANKYO COMPANY, LIMITED (JP) | 1999-01-05 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| US-5102997-A | Antibiotics | SANKYO COMPANY LIMITED (JP) | 1992-04-07 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
| EP-0102239-B1 | AZETIDINONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS INTERMEDIATES IN THE PREPARATION OF CARBAPENEM ANTIBIOTICS | SANKYO COMPANY LIMITED (JP) | 1987-10-14 | — | — | EP | disclosed |
| EP-0160391-A1 | Carbapenem derivatives and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-11-06 | — | — | EP | disclosed |
| EP-0102239-A1 | Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics | SANKYO COMPANY LIMITED (JP) | 1984-03-07 | — | — | EP | disclosed |