Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 2/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142075 | 0.78 | NPC1 (0.49) | TNK2KDRMAP2K1NPC1LMNA | |
| SCHEMBL2573277 | 0.78 | AHR (0.46) | TNK2KDRNPC1LMNARAB9A | |
| SCHEMBL6420521 | 0.76 | TDP1 (0.47) | TNK2MAP4K2MAP4K4KDRAURKB | |
| SCHEMBL10830686 | 0.76 | TNK2 (0.34) | TNK2CDK8ROCK1ALDH1A1ADORA2A | |
| SCHEMBL6506355 | 0.75 | PTPN5 (0.43) | MAP4K2MAP4K4KDRAURKBCSF1R | |
| SCHEMBL3607789 | 0.74 | CYP1A2 (0.36) | TNK2CSNK1EALDH1A1ADORA2AKMT2A | |
| SCHEMBL5315910 | 0.74 | MAP4K2 (0.42) | TNK2MAP4K2MAP4K4KDRAURKB | |
| Hydrochloric Acid SCHEMBL2573564 | 0.73 | CYP1A2 (0.35) | TNK2ALDH1A1KMT2A | |
| SCHEMBL6495619 | 0.73 | SYK (0.54) | TNK2MAP4K2MAP4K4KDRAURKB | |
| SCHEMBL6415711 | 0.73 | CSNK1E (0.43) | TNK2MAP4K2MAP4K4KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288502-A1 | Substituted heterocyclic compounds and methods of use | AMGEN, INC. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288502-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, IAPP, MAPT | TNK2 1983/4885MAP4K2 854/4885MAP4K4 679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.