Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 17/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 14/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 14/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6410425 | 0.99 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3ASMYD3 | |
| SCHEMBL5917865 | 0.81 | CHRNA7 (0.57) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6413582 | 0.80 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3ASMYD3 | |
| Hydrochloric Acid SCHEMBL6411766 | 0.80 | CHRNA7 (0.56) | CHRNA7CHRNB2CHRNA4HTR3A | |
| Hydrochloric Acid SCHEMBL6412402 | 0.80 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3ASMYD3 | |
| SCHEMBL6412711 | 0.79 | CHRNA7 (0.60) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL19740398 | 0.79 | CHRNA7 (0.55) | CHRNA7HTR3A | |
| SCHEMBL19739936 | 0.79 | CHRNA7 (0.55) | CHRNA7HTR3A | |
| SCHEMBL17842939 | 0.79 | CHRNA7 (0.55) | CHRNA7HTR3A | |
| Hydrochloric Acid SCHEMBL6411058 | 0.78 | CHRNA7 (0.59) | CHRNA7CHRNB2CHRNA4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215584-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | PFIZER INC | 2005-09-29 | — | — | US | disclosed |
| US-6858613-B2 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | PFIZER INC. (US) | 2005-02-22 | — | — | US | disclosed |
| US-20030236264-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236264-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | NAT1, CYP11B1, COASY | CHRNA7 1475/4885CHRNB2 3127/4885CHRNA4 2256/4885 |
| US-20050215584-A1 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease | CHRNA7, UGT2B7, CHRNA5 | CHRNA7 1/4885CHRNB2 39/4885CHRNA4 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.