Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 16/20 | 0.57 |
| ▸ | INSR | P06213 | 5/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6418932 | 0.86 | ITK (0.54) | ITKINSREGFRHRH4HRH3 | |
| SCHEMBL6418924 | 0.81 | ITK (0.46) | ITKINSRBACE1 | |
| SCHEMBL6273956 | 0.79 | ITK (0.55) | ITKINSREGFR | |
| SCHEMBL6270096 | 0.78 | GRM2 (0.49) | ITKINSREGFR | |
| SCHEMBL14699030 | 0.77 | ITK (0.68) | ITKINSR | |
| SCHEMBL6420483 | 0.74 | KDM4E (0.45) | ITKINSR | |
| SCHEMBL6271293 | 0.74 | JAK2 (0.45) | ITKINSR | |
| SCHEMBL6419560 | 0.74 | EGFR (0.43) | ITKINSREGFR | |
| SCHEMBL6270636 | 0.74 | CNR2 (0.40) | ITKINSR | |
| SCHEMBL6275914 | 0.73 | ITK (0.41) | ITKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209284-A1 | Tec kinase inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209284-A1 | Tec kinase inhibitors | TEC, ITK, TXK | ITK 2/4885INSR 910/4885EGFR 967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.