Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446243 | 0.86 | MCL1 (0.55) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL6419143 | 0.85 | HDAC3 (0.50) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Hydrochloric Acid SCHEMBL6417890 | 0.85 | MCL1 (0.53) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL446799 | 0.82 | KDM4E (0.58) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL2773751 | 0.68 | MCL1 (0.58) | PLK1MCL1KDM4EKCNH2AHR | |
| SCHEMBL4093872 | 0.68 | PLK1 (0.52) | PLK1MCL1KDM4EKCNH2AHR | |
| SCHEMBL8118132 | 0.68 | TSHR (0.56) | MCL1KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL13348987 | 0.67 | PLK1 (0.51) | PLK1MCL1KDM4EKCNH2AHR | |
| SCHEMBL28131940 | 0.67 | TEAD1 (0.51) | PLK1KDM4EAHRALDH1A1MAPT | |
| SCHEMBL10389855 | 0.66 | PLK1 (0.66) | PLK1MCL1KDM4EKCNH2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005118584-A2 | SAFRAMYCIN ANALOGS AS THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | AXYS PHARMACEUTICALS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |