Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRE11 | P49959 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NSD2 | O96028 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.52 |
| ▸ | NAT1 | P18440 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6419343 | 1.00 | MRE11 (0.64) | MRE11TDP1POLBKDM4ENSD2 | |
| SCHEMBL18102943 | 0.82 | PTP4A3 (0.75) | TDP1POLBKDM4ENSD2GAA | |
| SCHEMBL15421777 | 0.82 | NAT1 (0.72) | MRE11TDP1POLBKDM4ENSD2 | |
| SCHEMBL15421776 | 0.82 | NAT1 (0.72) | MRE11TDP1POLBKDM4ENSD2 | |
| SCHEMBL6416769 | 0.80 | PTPN1 (0.77) | MRE11TDP1POLBKDM4ENSD2 | |
| SCHEMBL6416767 | 0.80 | PTPN1 (0.77) | MRE11TDP1POLBKDM4ENSD2 | |
| SCHEMBL8172470 | 0.79 | TDP1 (0.70) | TDP1POLBKDM4ENSD2GAA | |
| SCHEMBL8172469 | 0.79 | TDP1 (0.70) | TDP1POLBKDM4ENSD2GAA | |
| Mirin SCHEMBL15421605 | 0.78 | MRE11 (1.00) | MRE11TDP1POLBMEN1KMT2A | |
| Mirin SCHEMBL21296287 | 0.78 | MRE11 (1.00) | MRE11TDP1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050019825-A9 | Common ligand mimics: pseudothiohydantoins | TRIAD THERAPEUTICS, INC. | 2005-01-27 | — | — | US | disclosed |
| US-20040009527-A1 | Common ligand mimics: pseudothiohydantoins | DONG QING (US) | 2004-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050019825-A9 | Common ligand mimics: pseudothiohydantoins | FGFR3, BID, FLT3 | MRE11 3352/4885TDP1 4871/4885POLB 4859/4885 |
| US-20040009527-A1 | Common ligand mimics: pseudothiohydantoins | FGFR3, BID, FLT3 | MRE11 3352/4885TDP1 4871/4885POLB 4859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.