Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 3/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7529917 | 0.83 | AOC3 (0.52) | AOC3PARP1PDK1PDK2PDK3 | |
| SCHEMBL7529041 | 0.83 | AOC3 (0.61) | AOC3PARP1 | |
| Trifluoroacetic Acid SCHEMBL7529674 | 0.82 | AOC3 (0.54) | AOC3PARP1PDK1PDK2PDK3 | |
| SCHEMBL7527574 | 0.82 | AOC3 (0.57) | AOC3PARP1PTGDR2PSEN1PSEN2 | |
| Trifluoroacetic Acid SCHEMBL7528873 | 0.81 | AOC3 (0.52) | AOC3PARP1PDK1PDK2PDK3 | |
| SCHEMBL1971755 | 0.80 | AOC3 (0.80) | AOC3PARP1PTGDR2 | |
| Hydrochloric Acid SCHEMBL11490292 | 0.80 | AOC3 (0.58) | AOC3PARP1PSEN1PSEN2APH1B | |
| SCHEMBL5645728 | 0.77 | AOC3 (0.43) | AOC3KDM4ELMNA | |
| SCHEMBL4760547 | 0.76 | AOC3 (0.43) | AOC3PARP1KDM4E | |
| SCHEMBL7528650 | 0.73 | AOC3 (0.51) | AOC3PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |