Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368985 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL584549 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL12824048 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL2683392 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL15909556 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL11099691 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL12235723 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL5155598 | 0.90 | NR1H2 (0.49) | NR1H2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL7712036 | 0.83 | NR1H2 (0.44) | NR1H2HPGDMEN1ALDH1A1MAPT | |
| SCHEMBL18461567 | 0.81 | CYP1A2 (0.41) | NR1H2HPGDMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2005232006-A | PYRROLIDINE DERIVATIVE AND METHOD FOR SYNTHESIZING THE SAME | EISAI CO LTD | 2005-09-02 | — | — | JP | disclosed |
| EP-1413574-A4 | PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE | EIZAI CO LTD (JP) | 2004-12-08 | — | — | EP | disclosed |
| EP-1413574-A1 | PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE | Eizai Co., Ltd. (JP) | 2004-04-28 | — | — | EP | disclosed |
| EP-1413574-A1 | PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE | Eizai Co., Ltd. (JP) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003011825-A1 | PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE | EIZAI CO.,LTD. (JP) | 2003-02-13 | — | — | WO | disclosed |