Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 16/20 | 0.62 |
| ▸ | PPARA | Q07869 | 11/20 | 0.62 |
| ▸ | PPARG | P37231 | 6/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017471 | 0.93 | PPARD (0.56) | PPARDPPARAPPARGFFAR1PTPN1 | |
| SCHEMBL5016717 | 0.91 | PPARD (0.74) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL6052571 | 0.91 | PPARD (0.51) | PPARDPPARAPPARGFFAR1PTPN1 | |
| SCHEMBL5015470 | 0.89 | PPARD (0.55) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL6109598 | 0.89 | PPARD (0.59) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL6109837 | 0.88 | PPARD (0.58) | PPARDPPARAPPARG | |
| SCHEMBL6222068 | 0.87 | PPARD (0.59) | PPARDPPARAPPARGFFAR1PTPN1 | |
| SCHEMBL6494057 | 0.86 | PPARD (0.60) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL5015489 | 0.85 | PPARD (0.55) | PPARDPPARAPPARGFFAR1PTPN1 | |
| SCHEMBL5015457 | 0.85 | PPARD (0.51) | PPARDPPARAPPARGFFAR1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | PPARD, PPARA, PPARG | PPARD 1/4885PPARA 2/4885PPARG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.