Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meglumine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 13/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856130 | 0.87 | FFAR1 (0.50) | FFAR1FFAR4SERPINE1MMP2MMP12 | |
| SCHEMBL1855658 | 0.87 | FFAR1 (0.50) | FFAR1FFAR4SERPINE1MMP2MMP12 | |
| SCHEMBL4671708 | 0.87 | FFAR1 (0.50) | FFAR1FFAR4SERPINE1MMP2MMP12 | |
| SCHEMBL1734792 | 0.77 | PTPN11 (0.49) | FFAR1FFAR4SERPINE1PTGESPTPN11 | |
| Meglumine SCHEMBL6422738 | 0.77 | FFAR1 (0.39) | FFAR1FFAR4MMP2MMP12PTGES | |
| SCHEMBL1851808 | 0.77 | FFAR1 (0.53) | FFAR1FFAR4MMP2MMP12PTGES | |
| SCHEMBL1852611 | 0.77 | FFAR1 (0.53) | FFAR1FFAR4MMP2MMP12PTGES | |
| SCHEMBL4669842 | 0.77 | FFAR1 (0.53) | FFAR1FFAR4MMP2MMP12PTGES | |
| SCHEMBL1851396 | 0.77 | FFAR1 (0.53) | FFAR1FFAR4MMP2MMP12PTGES | |
| SCHEMBL1852903 | 0.77 | FFAR1 (0.53) | FFAR1FFAR4MMP2MMP12PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | APPLIED RESEARCH SYSTEMS ARS (NL) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | PTPRS, PTPA, PTPMT1 | FFAR1 619/4885FFAR4 968/4885SERPINE1 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.