Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 20/20 | 0.72 |
| ▸ | HCRTR1 | O43613 | 18/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2130816 | 0.87 | HCRTR1 (0.69) | HCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL2025800 | 0.83 | HCRTR1 (1.00) | HCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL2136234 | 0.82 | HCRTR2 (0.73) | HCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL2135877 | 0.82 | HCRTR2 (0.74) | HCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL12700416 | 0.81 | HCRTR1 (0.61) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL2132818 | 0.80 | HCRTR1 (0.68) | HCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL2133982 | 0.80 | HCRTR1 (0.65) | HCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL2130371 | 0.80 | HCRTR2 (0.70) | HCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL2136120 | 0.79 | HCRTR1 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL2130316 | 0.78 | HCRTR1 (0.82) | HCRTR2HCRTR1KCNH2LTC4S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012055888-A1 | DIAZA-SPIRO[5.5]UNDECANES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2012-05-03 | — | — | WO | disclosed |