Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.49 |
| ▸ | PLK4 | O00444 | 7/20 | 0.47 |
| ▸ | AURKA | O14965 | 7/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.47 |
| ▸ | CSF1R | P07333 | 7/20 | 0.47 |
| ▸ | LYN | P07948 | 7/20 | 0.47 |
| ▸ | MET | P08581 | 7/20 | 0.47 |
| ▸ | KIT | P10721 | 7/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.47 |
| ▸ | BLK | P51451 | 7/20 | 0.47 |
| ▸ | NEK2 | P51955 | 7/20 | 0.47 |
| ▸ | STK3 | Q13188 | 7/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 7/20 | 0.47 |
| ▸ | FYN | P06241 | 6/20 | 0.47 |
| ▸ | ABL1 | P00519 | 6/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.47 |
| ▸ | FLT1 | P17948 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422866 | 0.88 | KDR (0.48) | KDRAURKBPLK4AURKAROCK2 | |
| SCHEMBL6422863 | 0.88 | KDR (0.48) | KDRAURKBPLK4AURKAROCK2 | |
| SCHEMBL6422858 | 0.85 | KDR (0.71) | KDRAURKBPLK4AURKAROCK2 | |
| SCHEMBL6422856 | 0.85 | KDR (0.71) | KDRAURKBPLK4AURKAROCK2 | |
| SCHEMBL6425053 | 0.84 | BTK (0.57) | KDRBTK | |
| SCHEMBL6425057 | 0.84 | BTK (0.57) | KDRBTK | |
| SCHEMBL3531993 | 0.82 | KDR (0.60) | KDRAURKBPLK4AURKAROCK2 | |
| SCHEMBL3532000 | 0.82 | KDR (0.60) | KDRAURKBPLK4AURKAROCK2 | |
| SCHEMBL6422548 | 0.79 | KDR (0.55) | KDRAURKBPLK4AURKAROCK2 | |
| SCHEMBL3529384 | 0.78 | KDR (0.73) | KDRAURKBPLK4AURKAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026944-A1 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026944-A1 | Thienopyridine and furopyridine kinase inhibitors | ABL1, ERBB2, LCK | KDR 494/4885AURKB 171/4885PLK4 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.