Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salsalate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.82 |
| ▸ | HPGD | P15428 | 8/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | GGT1 | P19440 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salsalate SCHEMBL3879224 | 1.00 | KDM4E (0.82) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL4090721 | 0.91 | HSD17B10 (0.70) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL15562 | 0.91 | HSD17B10 (1.00) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL2025628 | 0.91 | HSD17B10 (1.00) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL29362887 | 0.91 | HSD17B10 (1.00) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL4385161 | 0.89 | HSD17B10 (0.68) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL25177171 | 0.89 | KDM4E (0.96) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL9704557 | 0.89 | HSD17B10 (0.96) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| Salsalate SCHEMBL9624915 | 0.89 | HSD17B10 (0.96) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| SCHEMBL3264360 | 0.89 | HSD17B10 (0.96) | KDM4EHPGDHSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551370-A1 | AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN | IDEA AG (DE) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004032900-A1 | AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN | IDEA AG (DE) | 2004-04-22 | — | — | WO | disclosed |