Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422248 | 0.89 | HDAC1 (0.69) | HDAC6HDAC1CA1CA2HTR6 | |
| Hydrochloric Acid SCHEMBL9615118 | 0.88 | HDAC1 (0.67) | HDAC6HDAC1CA1CA2HTR6 | |
| Trifluoroacetic Acid SCHEMBL6425706 | 0.85 | HDAC6 (0.52) | HDAC6HDAC1HDAC8HTR6ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6424059 | 0.85 | HDAC6 (0.52) | HDAC6HDAC1HDAC8HTR6ALDH1A1 | |
| SCHEMBL6341009 | 0.85 | HDAC6 (0.71) | HDAC6HDAC1HDAC8CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6421091 | 0.84 | HDAC6 (0.51) | HDAC6HDAC1HDAC8HTR6ALDH1A1 | |
| SCHEMBL6333362 | 0.84 | HDAC6 (0.66) | HDAC6HDAC1CA1CA2HTR6 | |
| Hydrochloric Acid SCHEMBL6344225 | 0.83 | HDAC1 (0.65) | HDAC6HDAC1CA1CA2HTR6 | |
| Trifluoroacetic Acid SCHEMBL6421107 | 0.83 | HDAC6 (0.52) | HDAC6HDAC1HDAC8HTR6 | |
| Trifluoroacetic Acid SCHEMBL6422705 | 0.83 | HDAC6 (0.52) | HDAC6HDAC1HDAC8HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |