Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 15/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGR | P09769 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155295 | 0.93 | ABCB1 (0.42) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL447814 | 0.91 | KDR (0.49) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL6104937 | 0.89 | PDPK1 (0.44) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL447457 | 0.86 | KDR (0.54) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL447083 | 0.86 | KDR (0.50) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL444629 | 0.85 | KDR (0.49) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL446808 | 0.85 | KDR (0.49) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL7159530 | 0.85 | KDR (0.49) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL449890 | 0.85 | KDR (0.42) | ABCB1KDRCITMAP3K7RIPK2 | |
| SCHEMBL6105874 | 0.83 | KDR (0.42) | ABCB1KDRCITMAP3K7RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-6878714-B2 | Substituted alkylamine derivatives and methods of use | AMGEN INC. (US) | 2005-04-12 | — | — | US | disclosed |