Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | PRKACG | P22612 | 2/20 | 0.44 |
| ▸ | PRKACB | P22694 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424161 | 0.87 | PIM1 (0.47) | — | |
| SCHEMBL6424296 | 0.85 | CCNE2 (0.50) | — | |
| SCHEMBL6948330 | 0.85 | CCNE2 (0.54) | — | |
| SCHEMBL6427037 | 0.81 | CCNE2 (0.57) | — | |
| SCHEMBL6425680 | 0.79 | GSK3B (0.49) | — | |
| Enmd-981693 SCHEMBL608128 | 0.79 | CCNE2 (0.69) | — | |
| Enmd-981693 SCHEMBL29350364 | 0.79 | CCNE2 (0.69) | — | |
| SCHEMBL6956384 | 0.77 | CCNT1 (0.46) | — | |
| SCHEMBL6425419 | 0.76 | GSK3B (0.45) | — | |
| Hydrochloric Acid SCHEMBL6425416 | 0.76 | GSK3B (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242408-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | claimed |
| US-6313143-B1 | USEFUL IN THERAPY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | claimed |
| EP-1242408-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | disclosed |
| US-6313143-B1 | USEFUL IN THERAPY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |