Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.42 |
| ▸ | AURKA | O14965 | 6/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | STK25 | O00506 | 1/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | MUSK | O15146 | 1/20 | 0.35 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426047 | 0.87 | KDR (0.45) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL6425975 | 0.86 | AURKA (0.46) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL6428457 | 0.86 | KDR (0.46) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL6427399 | 0.86 | AURKA (0.43) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL6427742 | 0.85 | KDR (0.44) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL6426485 | 0.84 | AURKA (0.43) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL6428603 | 0.84 | KDR (0.44) | KDRAURKAAURKBCHEK1FGFR1 | |
| SCHEMBL5034271 | 0.84 | AURKA (0.43) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL5030054 | 0.83 | AURKA (0.44) | KDRAURKAAURKBTTKCHEK1 | |
| SCHEMBL4150362 | 0.82 | AURKA (0.49) | KDRAURKAAURKBTTKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | CNKSR1, NR3C2, CSNK2B | KDR 1044/4885AURKA 710/4885AURKB 579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.