Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426129 | 0.88 | KDR (0.47) | AURKAAURKBKDRFGFR1NPC1 | |
| SCHEMBL5030178 | 0.87 | AURKA (0.44) | AURKAAURKBKDRFGFR1LMNA | |
| SCHEMBL6426255 | 0.86 | KDR (0.45) | AURKAAURKBKDRFGFR1LMNA | |
| SCHEMBL5032415 | 0.85 | AURKA (0.44) | AURKAAURKBKDRFGFR1LMNA | |
| SCHEMBL6427399 | 0.83 | AURKA (0.43) | AURKAAURKBKDRFGFR1CSF1R | |
| SCHEMBL6427851 | 0.83 | CHEK1 (0.45) | AURKAAURKBKDRFGFR1CSF1R | |
| SCHEMBL5032410 | 0.83 | KDR (0.42) | AURKAAURKBKDRFGFR1 | |
| SCHEMBL13927681 | 0.81 | GSK3B (0.47) | AURKAAURKBKDRSMN1; SMN2MAPT | |
| SCHEMBL4135766 | 0.81 | AURKA (0.66) | AURKAAURKBKDRLMNA | |
| SCHEMBL4135771 | 0.81 | AURKA (0.66) | AURKAAURKBKDRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | CNKSR1, NR3C2, CSNK2B | AURKA 710/4885AURKB 579/4885KDR 1044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.