Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.66 |
| ▸ | RET | P07949 | 3/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.66 |
| ▸ | SRC | P12931 | 3/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.66 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.66 |
| ▸ | PLK4 | O00444 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | FYN | P06241 | 2/20 | 0.66 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.66 |
| ▸ | AXL | P30530 | 2/20 | 0.66 |
| ▸ | FRK | P42685 | 2/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.66 |
| ▸ | BLK | P51451 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479637 | 0.97 | RET (0.63) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6474265 | 0.95 | RAF1 (0.66) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6387944 | 0.92 | RET (0.63) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6384913 | 0.90 | RAF1 (0.66) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6382324 | 0.87 | RAF1 (0.65) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6385513 | 0.86 | RAF1 (0.60) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6384112 | 0.86 | RET (0.59) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6480098 | 0.86 | RAF1 (0.60) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL6381789 | 0.85 | KDR (0.60) | KDRRETMAPK14SRCAURKB | |
| SCHEMBL5569372 | 0.85 | KDR (0.74) | KDRRETMAPK14SRCAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608639-A2 | NOVEL BICYCLIC UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | Bayer Pharmaceuticals Corporation (US) | 2005-12-28 | — | — | EP | claimed |
| WO-2004078748-A2 | NOVEL BICYCLIC UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-09-16 | — | — | WO | claimed |