Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA1 | Q13131 | 13/20 | 0.79 |
| ▸ | KDR | P35968 | 12/20 | 0.79 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.79 |
| ▸ | EGFR | P00533 | 3/20 | 0.70 |
| ▸ | FLT3 | P36888 | 3/20 | 0.70 |
| ▸ | GRK5 | P34947 | 3/20 | 0.70 |
| ▸ | PLK4 | O00444 | 2/20 | 0.70 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.70 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.70 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.70 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.70 |
| ▸ | INSR | P06213 | 2/20 | 0.70 |
| ▸ | LCK | P06239 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16137746 | 1.00 | PRKAA1 (0.79) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL2114115 | 1.00 | PRKAA1 (0.79) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL31672544 | 1.00 | PRKAA1 (0.79) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL2113981 | 0.95 | KDR (0.72) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL13755215 | 0.95 | KDR (0.72) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL31672546 | 0.95 | KDR (0.72) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL17480339 | 0.94 | PRKAA1 (0.73) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL2114114 | 0.93 | KDR (0.79) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL13755225 | 0.93 | KDR (0.79) | PRKAA1KDRPRKAA2PDGFRBFGFR1 | |
| SCHEMBL16137745 | 0.93 | KDR (0.79) | PRKAA1KDRPRKAA2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572924-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572924-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7320996-B2 | Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer | SUGEN, INC (US) | 2008-01-22 | — | — | US | disclosed |
| US-7320996-B2 | Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer | SUGEN, INC (US) | 2008-01-22 | — | — | US | disclosed |
| US-20070010569-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. & PHARMACIA & UPJOHN CO. | 2007-01-11 | — | — | US | disclosed |
| US-20070010569-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. & PHARMACIA & UPJOHN CO. | 2007-01-11 | — | — | US | disclosed |
| US-6878733-B1 | Formulations for pharmaceutical agents ionizable as free acids or free bases | SUGEN, INC. (US) | 2005-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010569-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | PDPK1, PLK2, PNCK | PRKAA1 73/4885KDR 1387/4885PRKAA2 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.