SCHEMBL642714

SCHEMBL642714

O=C(O)C=CC=CC=CC=CC(=O)O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.61
TP53 P04637 1/20 0.61
EGLN1 Q9GZT9 1/20 0.61
EGLN3 Q9H6Z9 1/20 0.61
PPARA Q07869 1/20 0.41
GABRR1 P24046 2/20 0.40
GABRR2 P28476 2/20 0.40
BLM P54132 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
LMNA P02545 2/20 0.40
GABRR3 A8MPY1 1/20 0.40
APEX1 P27695 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
ACHE P22303 1/20 0.39
BACE1 P56817 1/20 0.39
MASP2 O00187 1/20 0.39
F2 P00734 1/20 0.39
ALDH1A1 P00352 2/20 0.39
HSD17B10 Q99714 2/20 0.39
ALOX15 P16050 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL642713 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL31715809 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL2558585 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL32684929 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL2552093 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL3503306 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL32684741 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL2552092 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL2989833 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA
SCHEMBL2989831 1.00 TSHR (0.61) TSHRTP53EGLN1EGLN3PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011124227-A1 BIOCIDAL ACID-ADJUSTED POLYMER WITH POLYPROPYLENE VESTERGAARD FRANDSEN SA (CH) 2011-10-13 WO claimed
WO-2011124228-A1 A BIOCIDAL POLYOLEFIN YARN WITH 3-12 FILAMENTS VESTERGAARD FRANDSEN SA (CH) 2011-10-13 WO claimed
US-20250249024-A1 METHODS AND COMPOSITIONS RELATED TO GLUCOCORTICOID RECEPTOR ANTAGONISTS AND BREAST CANCER THE UNIVERSITY OF CHICAGO (US) 2025-08-07 US disclosed
US-20250154597-A1 TRANSCRIPTIONAL REPROGRAMMING DIFFERENTIATES ACTIVE FROM INACTIVE ESR1 FUSIONS IN ENDOCRINE THERAPY-REFRACTORY METASTATIC BREAST CANCER BAYLOR COLLEGE OF MEDICINE (US) 2025-05-15 US disclosed
US-12280066-B2 Methods and compositions related to glucocorticoid receptor antagonists and breast cancer THE UNIVERSITY OF CHICAGO (US) 2025-04-22 US disclosed
US-20240355476-A1 METHODS AND COMPOSITIONS RELATED TO TRIPLE-NEGATIVE BREAST CANCER THE UNIVERSITY OF CHICAGO (US) 2024-10-24 US disclosed
EP-4416307-A2 TRANSCRIPTIONAL REPROGRAMMING DIFFERENTIATES ACTIVE FROM INACTIVE ESR1 FUSIONS IN ENDOCRINE THERAPY-REFRACTORY METASTATIC BREAST CANCER Baylor College of Medicine (US) 2024-08-21 EP disclosed
EP-3912626-B1 METHODS AND COMPOSITIONS RELATED TO GLUCOCORTICOID RECEPTOR ANTAGONISM AND PROSTATE CANCER UNIV CHICAGO (US) 2024-08-21 EP disclosed
US-12062444-B2 Methods and compositions related to triple-negative breast cancer THE UNIVERSITY OF CHICAGO (US) 2024-08-13 US disclosed
US-20240148754-A1 METHODS AND COMPOSITIONS RELATED TO GLUCOCORTICOID RECEPTOR ANTAGONISTS AND BREAST CANCER THE UNIVERSITY OF CHICAGO 2024-05-09 US disclosed
US-11883417-B2 Methods and compositions related to glucocorticoid receptor antagonists and breast cancer THE UNIVERSITY OF CHICAGO (US) 2024-01-30 US disclosed
WO-2007071440-A1 INHIBITORS OF CCR9 ACTIVITY NOVARTIS AG (CH) 2007-06-28 WO disclosed
WO-2007071443-A1 INHIBITORS OF CCR9 ACTIVITY NOVARTIS AG (CH) 2007-06-28 WO disclosed
WO-2007057457-A2 NEUROENDOCRINE TUMOR TREATMENT USING MTOR INHIBITORS NOVARTIS AG (CH) 2007-05-24 WO disclosed
EP-1230238-B1 PROCESS FOR THE PREPARATION OF FUMAGILLIN SANOFI AVENTIS (FR) 2007-05-02 EP disclosed
US-6521764-B1 Stable Fumagillin dicyclohexylamine salt used in veterinary medicine is reacted with an organic acid in alcoholic medium to free the salt SANOFI-SYNTHELABO (FR) 2003-02-18 US disclosed
EP-1230238-A2 PROCESS FOR THE PREPARATION OF FUMAGILLIN Sanofi-Aventis (FR) 2002-08-14 EP disclosed
WO-2000076994-A2 PROCESS FOR THE PREPARATION OF FUMAGILLIN SANOFI-SYNTHELABO (FR) 2000-12-21 WO disclosed
US-5900431-A Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections SANOFI (FR) 1999-05-04 US disclosed
WO-1994019946-A1 TREATMENT OF MICROSPORIDIAL AND ACANTHAMOEBA KERATOCONJUNCTIVITIS WITH TOPICAL FUMAGILLIN EMORY UNIVERSITY (US) 1994-09-15 WO disclosed