SCHEMBL6427388 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	2/20	0.39

▸	JAK1	P23458	2/20	0.39

▸	P2RX7	Q99572	1/20	0.36

▸	CNR2	P34972	2/20	0.36

▸	ALDH1A1	P00352	1/20	0.35

▸	NPSR1	Q6W5P4	1/20	0.35

▸	PDGFRB	P09619	3/20	0.35

▸	PDGFRA	P16234	3/20	0.35

▸	PDE3B	Q13370	1/20	0.35

▸	PDE3A	Q14432	1/20	0.35

▸	HSP90AA1	P07900	2/20	0.35

▸	JAK3	P52333	1/20	0.34

▸	HRH4	Q9H3N8	3/20	0.34

▸	BRS3	P32247	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1605102	0.74	CYP1A2 (0.39)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL1604424	0.74	CYP1A2 (0.39)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL1604427	0.74	CYP1A2 (0.39)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL14531385	0.74	CYP1A2 (0.39)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL6427392	0.73	JAK2 (0.36)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL1382675	0.72	JAK2 (0.36)	JAK2JAK1P2RX7CNR2PDGFRB
SCHEMBL1605173	0.72	JAK2 (0.36)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL1604799	0.72	JAK2 (0.36)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL1604796	0.72	JAK2 (0.36)	JAK2JAK1P2RX7CNR2ALDH1A1
SCHEMBL1605526	0.72	JAK2 (0.36)	JAK2JAK1P2RX7CNR2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2005075471-A2	THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS	BIOVITRUM AB (SE)	2005-08-18	—	—	WO	disclosed