Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092099 | 0.78 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL4092785 | 0.72 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL4081991 | 0.72 | ABL1 (0.61) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL4092473 | 0.70 | ABL1 (0.60) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL28673163 | 0.54 | CNR2 (0.47) | ALDH1A1 | |
| SCHEMBL20689624 | 0.54 | TYK2 (0.47) | ALDH1A1KDM4ENPC1RAB9AALOX15 | |
| SCHEMBL1966568 | 0.53 | NR1H2 (0.39) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL4464429 | 0.53 | PIK3CA (0.52) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL14791071 | 0.52 | MAPT (0.37) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL26246483 | 0.52 | CNR2 (0.39) | ALDH1A1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496900-A2 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON ANTICHOLINERGICS AND P38 KINASE INHIBITORS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003084539-A2 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON ANTICHOLINERGICS AND P38 KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-10-16 | — | — | WO | disclosed |