Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7385715 | 0.98 | GRM5 (0.61) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7389576 | 0.89 | GRM5 (0.67) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL7418874 | 0.87 | GRM5 (0.65) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13377842 | 0.83 | GRM5 (0.57) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL596744 | 0.75 | APP (0.50) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4858200 | 0.75 | PDGFRB (0.46) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL4864461 | 0.73 | PDGFRB (0.45) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10277252 | 0.72 | APP (0.52) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL15947628 | 0.72 | CYP1A2 (0.55) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| Diphenylacetylene SCHEMBL29188592 | 0.71 | APP (1.00) | GRM5NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599204-A2 | SELECTIVE MGLU5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT | Recordati Ireland Limited (IE) | 2005-11-30 | — | — | EP | disclosed |
| US-20040215284-A1 | Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists | RECORDATI S.A. | 2004-10-28 | — | — | US | disclosed |
| WO-2004067002-A2 | SELECTIVE mGlu5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT | RECORDATI IRELAND LIMITED (IE) | 2004-08-12 | — | — | WO | disclosed |