Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 13/20 | 0.82 |
| ▸ | LCK | P06239 | 10/20 | 0.82 |
| ▸ | SRC | P12931 | 9/20 | 0.82 |
| ▸ | TEK | Q02763 | 9/20 | 0.82 |
| ▸ | KDR | P35968 | 4/20 | 0.82 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.70 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.70 |
| ▸ | LYN | P07948 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | CSK | P41240 | 2/20 | 0.60 |
| ▸ | BLK | P51451 | 2/20 | 0.60 |
| ▸ | ITK | Q08881 | 2/20 | 0.60 |
| ▸ | FGR | P09769 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | PAK4 | O96013 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804551 | 1.00 | BTK (0.82) | BTKLCKSRCTEKKDR | |
| SCHEMBL5804554 | 1.00 | BTK (0.82) | BTKLCKSRCTEKKDR | |
| Maleic Acid SCHEMBL5801746 | 0.94 | BTK (0.72) | BTKLCKSRCTEKKDR | |
| Maleic Acid SCHEMBL5801744 | 0.94 | BTK (0.72) | BTKLCKSRCTEKKDR | |
| Fumaric Acid SCHEMBL5801750 | 0.94 | BTK (0.72) | BTKLCKSRCTEKKDR | |
| Fumaric Acid SCHEMBL5801748 | 0.94 | BTK (0.72) | BTKLCKSRCTEKKDR | |
| SCHEMBL25468776 | 0.93 | BTK (0.81) | BTKLCKSRCTEKKDR | |
| SCHEMBL6433141 | 0.90 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| SCHEMBL6430568 | 0.90 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| SCHEMBL6430567 | 0.90 | BTK (1.00) | BTKLCKSRCTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | BTK 1020/4885LCK 1011/4885SRC 1834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.