Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 12/20 | 0.66 |
| ▸ | CA1 | P00915 | 12/20 | 0.66 |
| ▸ | CA2 | P00918 | 12/20 | 0.66 |
| ▸ | CA4 | P22748 | 12/20 | 0.66 |
| ▸ | CA7 | P43166 | 12/20 | 0.66 |
| ▸ | CA9 | Q16790 | 12/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.66 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | S100A4 | P26447 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263316 | 1.00 | CA12 (0.66) | CA12CA1CA2CA4CA7 | |
| SCHEMBL5575433 | 0.89 | TRPV1 (0.66) | CA12CA1CA2CA4CA7 | |
| SCHEMBL6864670 | 0.88 | KMT2A (0.68) | CA12CA1CA2CA4CA7 | |
| SCHEMBL6576549 | 0.88 | KMT2A (0.68) | CA12CA1CA2CA4CA7 | |
| SCHEMBL1351080 | 0.83 | SYK (0.63) | CA12CA1CA2CA4CA7 | |
| SCHEMBL1351078 | 0.83 | SYK (0.63) | CA12CA1CA2CA4CA7 | |
| SCHEMBL2000948 | 0.81 | KDM4E (0.65) | CA12CA1CA2CA4CA7 | |
| SCHEMBL13211953 | 0.81 | TRPV1 (0.56) | CA12CA1CA2CA4CA7 | |
| SCHEMBL13005148 | 0.81 | TRPV1 (0.57) | CA12CA1CA2CA4CA7 | |
| SCHEMBL26701268 | 0.80 | TRPV1 (0.81) | CA12CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572237-A1 | COMBINATIONS OF VANILLOID ANTAGONIST AND NSAID FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056394-A1 | COMBINATIONS OF A VANILLOID ANTAGONIST AND AN NSAID FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |