Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312287 | 0.82 | KMT2A (0.92) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL8775686 | 0.81 | KMT2A (0.65) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL9710250 | 0.80 | KMT2A (0.69) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL8961446 | 0.79 | KMT2A (0.79) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL3083135 | 0.79 | KMT2A (0.79) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| Benzyl Benzoate SCHEMBL901058 | 0.79 | KMT2A (1.00) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL5085718 | 0.79 | KMT2A (0.92) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| Benzyl Benzoate SCHEMBL8010992 | 0.79 | KMT2A (1.00) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| Benzyl Benzoate SCHEMBL3038 | 0.79 | KMT2A (1.00) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL704543 | 0.78 | KMT2A (0.71) | KMT2ATDP1SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927049-B1 | LABELLED ELASTASE INHIBITORS | AMERSHAM PLC (GB) | 2005-05-11 | — | — | EP | disclosed |
| US-6375926-B1 | HUMAN LEUCOCYTE ELASTASE (HLE) INHIBITOR LABELLED WITH A DETECTABLE MOIETY WHERE THE INHIBITOR IS SYNTHETIC AND THE DETECTABLE MOIETY IS CHOSEN FROM A RADIOACTIVE ISOTOPE, A PARAMAGNETIC ION, A RADIOPAQUE COMPOUND AND AN ULTRASOUND | AMERSHAM INTERNATIONAL PLC | 2002-04-23 | — | — | US | disclosed |
| EP-0927049-A2 | LABELLED ELASTASE INHIBITORS | AMERSHAM INTERNATIONAL plc (GB) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998010800-A2 | LABELLED ELASTASE INHIBITORS | AMERSHAM INTERNATIONAL PLC (GB) | 1998-03-19 | — | — | WO | disclosed |