Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.54 |
| ▸ | IGF1R | P08069 | 11/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 11/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 11/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438071 | 0.79 | EGFR (0.59) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6222131 | 0.73 | EGFR (0.79) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6222127 | 0.73 | EGFR (0.79) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL5801898 | 0.73 | SRC (0.54) | EGFRKDRSRCPIK3CDABL1 | |
| SCHEMBL14268429 | 0.71 | EGFR (0.79) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL14268423 | 0.70 | IGF1R (0.84) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6431591 | 0.70 | EGFR (1.00) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6430510 | 0.70 | EGFR (1.00) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6430512 | 0.70 | EGFR (1.00) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL5801670 | 0.69 | KDM4E (0.41) | EGFRKDRSRCPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-20050008640-A1 | Method of treating transplant rejection | ABBOTT LABORATORIES | 2005-01-13 | — | — | US | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008640-A1 | Method of treating transplant rejection | LCK, ZAP70, FYN | EGFR 818/4885ERBB2 894/4885IGF1R 4007/4885 |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | EGFR 2229/4885ERBB2 529/4885IGF1R 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.