Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.52 |
| ▸ | HTT | P42858 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431957 | 1.00 | MAPT (0.52) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6431942 | 0.92 | MAPT (0.51) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6431936 | 0.92 | MAPT (0.51) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6417904 | 0.90 | MAPT (0.53) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6417899 | 0.90 | MAPT (0.53) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6436226 | 0.87 | MAPT (0.51) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6439515 | 0.87 | MAPT (0.51) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6419561 | 0.87 | MAPT (0.53) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6417041 | 0.83 | KMT2A (0.43) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6432233 | 0.83 | GAA (0.44) | MAPTKDM4EHTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019220-A9 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS MODULATORS OF KINASE ACTIVITY | CELLULAR GENOMICS INC (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |