Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 10/20 | 0.75 |
| ▸ | KDR | P35968 | 9/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.75 |
| ▸ | EGFR | P00533 | 4/20 | 0.55 |
| ▸ | FLT4 | P35916 | 4/20 | 0.55 |
| ▸ | SRC | P12931 | 8/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6432200 | 0.99 | FLT1 (0.74) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6431198 | 0.86 | FLT1 (1.00) | FLT1KDRFGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6431524 | 0.85 | FLT1 (0.98) | FLT1KDRFGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6431009 | 0.83 | FLT1 (0.52) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6431742 | 0.83 | FLT1 (0.61) | FLT1KDRFGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6431020 | 0.82 | FLT1 (0.61) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6431782 | 0.82 | SRC (0.60) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6432228 | 0.81 | FLT1 (0.61) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL6430810 | 0.79 | FGFR1 (0.51) | FLT1KDRFGFR1EGFRSRC | |
| Hydrochloric Acid SCHEMBL6434964 | 0.78 | FLT1 (0.82) | FLT1KDRFGFR1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | claimed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | claimed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | claimed |
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |