Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886299 | 0.73 | HSD17B10 (0.54) | KDM4EHSD17B10ALDH1A1HPGDPDE3B | |
| SCHEMBL1352172 | 0.70 | MEN1 (0.55) | KDM4EHSD17B10ALDH1A1HPGDPDE3B | |
| SCHEMBL4887564 | 0.70 | PDE3B (0.45) | KDM4EHSD17B10ALDH1A1HPGDPDE3B | |
| SCHEMBL4891258 | 0.70 | KDM4E (0.42) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL4888765 | 0.69 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL18190702 | 0.69 | KDM4E (0.49) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL4890983 | 0.68 | PDE3B (0.54) | KDM4EHSD17B10ALDH1A1HPGDPDE3B | |
| SCHEMBL31672793 | 0.67 | KDM4E (0.36) | KDM4EALDH1A1PDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL10809624 | 0.66 | PDE3B (0.60) | KDM4EALDH1A1PDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL10812608 | 0.66 | PDE3B (0.60) | KDM4EHSD17B10ALDH1A1HPGDPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010699-B1 | 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | DAINIPPON PHARMACEUTICAL CO (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-6277993-B1 | USEFUL AS A BENZODIAZEPINE INVERSE AGONIST, FOR EXAMPLE, AS PSYCHOANALEPTIC DRUG OR DRUG FOR TREATMENT OF DYSMNESIA IN SENILE DEMENTIA OR ALZHEIMER'S DISEASE | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-08-21 | — | — | US | disclosed |
| US-6172079-B1 | BENZODIAZEPINE INVERSE AGONISTS; ALZHEIMER*S DISEASE; ANXIOLYTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS, ANTIEPILEPTIC AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-1010699-A1 | 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2000-06-21 | — | — | EP | disclosed |