Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.56 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.56 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | BLK | P51451 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6432462 | 0.94 | BTK (0.59) | BTKNUDT14NUDT5LCKLYN | |
| Acetic Acid SCHEMBL6461687 | 0.92 | BTK (0.64) | BTKNUDT14NUDT5LCKLYN | |
| SCHEMBL27604370 | 0.89 | BTK (0.69) | BTKNUDT14NUDT5LCKLYN | |
| SCHEMBL6434082 | 0.87 | BTK (0.60) | BTKNUDT14NUDT5LCKLYN | |
| SCHEMBL6466034 | 0.84 | BTK (0.65) | BTKNUDT14NUDT5LCKLYN | |
| Acetic Acid SCHEMBL4818712 | 0.84 | BTK (0.71) | BTKNUDT14NUDT5LCKLYN | |
| 2-Bromoethanol SCHEMBL6433498 | 0.83 | BTK (0.66) | BTKNUDT14NUDT5LCKLYN | |
| SCHEMBL5803152 | 0.81 | BTK (0.70) | BTKNUDT14NUDT5LCKLYN | |
| SCHEMBL5801655 | 0.79 | BTK (0.71) | BTKNUDT14NUDT5LCKLYN | |
| SCHEMBL6430574 | 0.79 | BTK (0.66) | BTKNUDT14NUDT5LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |