SCHEMBL6433108

SCHEMBL6433108

CCOC(=O)c1ccnc(-c2cccc([N+](=O)[O-])c2)c1

nearest known ligand 0.67

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.62
KMT2A Q03164 4/20 0.53
MEN1 O00255 3/20 0.53
RAB9A P51151 1/20 0.53
ALDH1A1 P00352 2/20 0.52
MAPK1 P28482 1/20 0.52
JMJD6 Q6NYC1 4/20 0.51
SLC6A2 P23975 1/20 0.51
SLC6A4 P31645 1/20 0.51
SLC6A3 Q01959 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
JMJD7 P0C870 1/20 0.49
ALOX12 P18054 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3388760 0.84 NPC1 (0.62) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL27553467 0.82 IDO1 (0.52) MAPTKMT2AMEN1RAB9AALDH1A1
SCHEMBL1279957 0.82 MAPT (0.56) MAPTKMT2AMEN1RAB9AALDH1A1
Hydrochloric Acid SCHEMBL29506783 0.82 NPC1 (0.61) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
Fluoride SCHEMBL27588568 0.82 NPC1 (0.61) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
Ammonia Solution, Strong SCHEMBL9555537 0.82 NPC1 (0.61) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL22206185 0.82 MAPT (0.60) MAPTKMT2AMEN1RAB9AALDH1A1
SCHEMBL29838321 0.82 MAPT (0.60) MAPTKMT2AMEN1RAB9AALDH1A1
SCHEMBL31417865 0.82 JMJD6 (0.56) MAPTRAB9AALDH1A1JMJD6SMN1; SMN2
SCHEMBL4763680 0.81 JMJD6 (0.67) MAPTRAB9AALDH1A1JMJD6SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1087943-B1 THERAPEUTIC BIARYL DERIVATIVES GLAXO GROUP LTD (GB) 2005-08-17 EP disclosed
CN-1214008-C Therapeutic biaryl derivatives GLAXO GROUP LTD (GB) 2005-08-10 CN disclosed
CN-1312800-A Therapeutic biaryl derivatives GLAXO GROUP LTD (GB) 2001-09-12 CN disclosed
US-6251925-B1 AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR GLAXO WELLCOME INC. 2001-06-26 US disclosed
EP-1087943-A1 THERAPEUTIC BIARYL DERIVATIVES GLAXO GROUP LIMITED (GB) 2001-04-04 EP disclosed
WO-1999065877-A1 THERAPEUTIC BIARYL DERIVATIVES GLAXO GROUP LIMITED (GB) 1999-12-23 WO disclosed