Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164141 | 0.93 | CYP3A4 (0.46) | GRM2 | |
| SCHEMBL6168384 | 0.93 | CYP3A4 (0.46) | GRM2 | |
| SCHEMBL6434671 | 0.91 | — | — | |
| SCHEMBL6433638 | 0.85 | CYP3A4 (0.49) | GRM2 | |
| SCHEMBL6434143 | 0.85 | CYP3A4 (0.49) | GRM2 | |
| SCHEMBL6434101 | 0.85 | CYP3A4 (0.62) | GRM2 | |
| SCHEMBL6433497 | 0.83 | GRM2 (0.64) | GRM2 | |
| SCHEMBL6167287 | 0.83 | CYP3A4 (0.49) | GRM2 | |
| SCHEMBL6164959 | 0.83 | CYP3A4 (0.44) | — | |
| SCHEMBL6434141 | 0.81 | GRM2 (0.64) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379522-B1 | DIHYDRO-BENZO(b)(1,4)DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I | HOFFMANN LA ROCHE (CH) | 2005-01-26 | — | — | EP | disclosed |
| US-6548495-B2 | Metabotropic glutamate receptor agonist for treatment or prevention of acute and/or chronic neurological disorders | HOFFMANN-LA ROCHE INC. | 2003-04-15 | — | — | US | disclosed |