Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 20/20 | 0.82 |
| ▸ | FNTB | P49356 | 19/20 | 0.82 |
| ▸ | PGGT1B | P53609 | 18/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | DNAJA1 | P31689 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1434347 | 0.90 | FNTA (1.00) | FNTAFNTBPGGT1BKCNH2CYP3A4 | |
| SCHEMBL7186917 | 0.82 | FNTA (0.72) | FNTAFNTBPGGT1BKCNH2CYP3A4 | |
| SCHEMBL7160364 | 0.80 | FNTA (0.79) | FNTAFNTBPGGT1BKCNH2CYP3A4 | |
| SCHEMBL7163961 | 0.79 | FNTA (1.00) | FNTAFNTBPGGT1BKCNH2CYP3A4 | |
| SCHEMBL7160377 | 0.79 | FNTA (0.82) | FNTAFNTBPGGT1BDNAJA1 | |
| SCHEMBL7163748 | 0.79 | FNTA (1.00) | FNTAFNTBPGGT1BDNAJA1 | |
| SCHEMBL7160573 | 0.79 | FNTA (1.00) | FNTAFNTBPGGT1BDNAJA1 | |
| SCHEMBL3516578 | 0.77 | FNTA (1.00) | FNTAFNTBPGGT1BKCNH2CYP3A4 | |
| SCHEMBL7160351 | 0.77 | FNTA (1.00) | FNTAFNTBPGGT1BDNAJA1 | |
| SCHEMBL29564445 | 0.77 | FNTA (1.00) | FNTAFNTBPGGT1BKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | claimed |
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |