Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.77 |
| ▸ | LCK | P06239 | 11/20 | 0.77 |
| ▸ | SRC | P12931 | 9/20 | 0.77 |
| ▸ | TEK | Q02763 | 8/20 | 0.77 |
| ▸ | KDR | P35968 | 4/20 | 0.77 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.66 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | ITK | Q08881 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | YES1 | P07947 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
| ▸ | FGR | P09769 | 1/20 | 0.56 |
| ▸ | FER | P16591 | 1/20 | 0.56 |
| ▸ | CSK | P41240 | 1/20 | 0.56 |
| ▸ | TEC | P42680 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433399 | 1.00 | BTK (0.77) | BTKLCKSRCTEKKDR | |
| SCHEMBL6431161 | 0.94 | LCK (0.80) | BTKLCKSRCTEKKDR | |
| SCHEMBL6431160 | 0.94 | LCK (0.80) | BTKLCKSRCTEKKDR | |
| SCHEMBL6430986 | 0.92 | BTK (0.79) | BTKLCKSRCTEKKDR | |
| SCHEMBL6430989 | 0.92 | BTK (0.79) | BTKLCKSRCTEKKDR | |
| SCHEMBL6430567 | 0.88 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| SCHEMBL6430568 | 0.88 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| SCHEMBL6433141 | 0.88 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| SCHEMBL29763088 | 0.88 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| Acetic Acid SCHEMBL7046568 | 0.87 | LCK (0.61) | BTKLCKSRCTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-20050008640-A1 | Method of treating transplant rejection | ABBOTT LABORATORIES | 2005-01-13 | — | — | US | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008640-A1 | Method of treating transplant rejection | LCK, ZAP70, FYN | BTK 42/4885LCK 1/4885SRC 46/4885 |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | BTK 1020/4885LCK 1011/4885SRC 1834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.