Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 12/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 11/20 | 0.55 |
| ▸ | TEK | Q02763 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 10/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.53 |
| ▸ | ABL1 | P00519 | 8/20 | 0.53 |
| ▸ | HCK | P08631 | 8/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.53 |
| ▸ | MTOR | P42345 | 8/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.53 |
| ▸ | PRKDC | P78527 | 8/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6431342 | 0.99 | LCK (0.56) | LCKAURKAIKBKEAURKBKDR | |
| SCHEMBL5804562 | 0.91 | AURKA (0.56) | LCKAURKAIKBKEAURKBKDR | |
| SCHEMBL6431567 | 0.90 | LCK (0.57) | LCKAURKAIKBKEAURKBKDR | |
| Hydrochloric Acid SCHEMBL27586575 | 0.89 | LCK (0.53) | LCKKDRSRCTEKEGFR | |
| SCHEMBL6430399 | 0.88 | LCK (0.72) | LCKAURKAIKBKEAURKBKDR | |
| SCHEMBL6430396 | 0.88 | LCK (0.72) | LCKAURKAIKBKEAURKBKDR | |
| SCHEMBL5802530 | 0.88 | LCK (0.54) | LCKAURKAIKBKEAURKBKDR | |
| SCHEMBL6430834 | 0.87 | LCK (0.53) | LCKAURKAIKBKEAURKBKDR | |
| Acetic Acid SCHEMBL6435206 | 0.87 | LCK (0.71) | LCKAURKAIKBKEAURKBKDR | |
| Acetic Acid SCHEMBL6435211 | 0.87 | LCK (0.71) | LCKAURKAIKBKEAURKBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| CN-1520298-A | Pyrazolopyrimidines as therapeutic agents | �����ʩ���عɷݹ�˾ | 2004-08-11 | — | — | CN | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | LCK 1011/4885AURKA 443/4885IKBKE 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.