Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.64 |
| ▸ | LCK | P06239 | 4/20 | 0.64 |
| ▸ | LYN | P07948 | 2/20 | 0.64 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.62 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | ITK | Q08881 | 3/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | YES1 | P07947 | 1/20 | 0.60 |
| ▸ | HCK | P08631 | 1/20 | 0.60 |
| ▸ | FGR | P09769 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | FER | P16591 | 1/20 | 0.60 |
| ▸ | CSK | P41240 | 1/20 | 0.60 |
| ▸ | TEC | P42680 | 1/20 | 0.60 |
| ▸ | BLK | P51451 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430310 | 0.91 | BTK (0.64) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL7697145 | 0.90 | BTK (0.62) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6431679 | 0.89 | BTK (0.61) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6430574 | 0.89 | BTK (0.66) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5805112 | 0.88 | BTK (0.60) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5802228 | 0.87 | BTK (0.58) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL28901192 | 0.86 | BTK (0.68) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6430246 | 0.85 | BTK (0.56) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL28409293 | 0.84 | BTK (0.73) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL28409359 | 0.84 | BTK (0.73) | BTKLCKLYNNUDT14NUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |