Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487988 | 0.88 | CCNE1 (0.45) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5481490 | 0.86 | CCNE1 (0.51) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5490522 | 0.84 | CCNE1 (0.46) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5484166 | 0.82 | CCNE1 (0.47) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5481063 | 0.78 | CCNE1 (0.53) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5477878 | 0.78 | CCNE1 (0.53) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5481330 | 0.77 | CCNE1 (0.52) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5483023 | 0.77 | CCNE1 (0.54) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5481136 | 0.77 | CCNE1 (0.56) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5478300 | 0.76 | CDK2 (0.53) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004120-A1 | Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents | PHARMACIA ITALIS S.P.A. (IT) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004120-A1 | Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents | CCAR2, BCL2, ROS1 | CCNE1 513/4885CDK2 26/4885CDK5 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.