SCHEMBL6435170

SCHEMBL6435170

COc1ccc2cc(C(=O)NCc3ccc(N(C)C)cc3)n(Cc3cccc(C(N)=S)c3)c2c1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.60
F2 P00734 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6434653 0.87 F10 (0.54) F10F2
SCHEMBL6436370 0.84 F10 (0.72) F10F2
SCHEMBL6434144 0.84 F10 (0.52) F10
SCHEMBL6433197 0.79 F10 (0.68) F10F2
SCHEMBL6432363 0.78 F10 (0.63) F10F2
Trifluoroacetic Acid SCHEMBL6432953 0.76 F10 (1.00) F10F2
SCHEMBL6433029 0.75 F10 (0.62) F10F2
SCHEMBL6432955 0.75 F10 (0.88) F10F2
SCHEMBL6436996 0.75 F10 (0.71) F10F2
Trifluoroacetic Acid SCHEMBL6432949 0.74 F10 (0.96) F10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042287-B1 INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA AVENTIS PHARMA GMBH (DE) 2005-04-20 EP disclosed
US-6337344-B1 ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-01-08 US disclosed