⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435977 | 1.00 | — | — | |
| SCHEMBL6760404 | 0.80 | AURKA (0.30) | — | |
| SCHEMBL10048733 | 0.75 | — | — | |
| SCHEMBL6627639 | 0.74 | — | — | |
| SCHEMBL616429 | 0.73 | — | — | |
| SCHEMBL616428 | 0.73 | — | — | |
| SCHEMBL4405916 | 0.73 | AURKA (0.33) | — | |
| SCHEMBL4402294 | 0.73 | AURKA (0.33) | — | |
| SCHEMBL31437498 | 0.73 | AURKA (0.33) | — | |
| SCHEMBL23922826 | 0.72 | CCNB2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254908-B9 | Preparation of a camptothecin derivative by intramolecular cyclisation | OSI PHARM INC (US) | 2005-09-21 | — | — | EP | disclosed |
| EP-1254908-B1 | Preparation of a camptothecin derivative by intramolecular cyclisation | OSI PHARM INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6821982-B2 | Preparation of a camptothecin derivative by intramolecular cyclisation | OSI PHARMACEUTICALS, INC. | 2004-11-23 | — | — | US | disclosed |
| EP-0758333-B1 | INTERMEDIATES IN PHARMACEUTICAL CAMPTOTHECIN PREPARATION | OSI PHARM INC (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030204088-A1 | Preparation of a camptothecin derivative by intramolecular cyclisation | OSI PHARMACEUTICALS, INC. | 2003-10-30 | — | — | US | disclosed |
| US-6559309-B2 | Preparation for camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. The process for the preparation of the camptothecin derivative known by 7-(4 | OSI PHARMACEUTICALS, INC. | 2003-05-06 | — | — | US | disclosed |
| US-20030045719-A1 | Preparation of a camptothecin derivative by intramolecular cyclisation | OSI PHARMACEUTICALS, INC. | 2003-03-06 | — | — | US | disclosed |
| EP-1254908-A1 | Preparation of a camptothecin derivative by intramolecular cyclisation | GILEAD SCIENCES, INC. (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0758335-B1 | PREPARATION OF A CAMPTOTHECIN DERIVATIVE BY INTRAMOLECULAR CYCLISATION | GILEAD SCIENCES INC (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6462196-B1 | NOVEL INTERMEDIATES USED IN THE PREPARATION OF CAMPTOTHECIN DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2002-10-08 | — | — | US | disclosed |
| US-6063923-A | Preparation of a camptothecin derivative by intramolecular cyclisation | GLAXO WELLCOME INC. (US) | 2000-05-16 | — | — | US | disclosed |
| US-5840898-A | Method of removing heavy metal contaminants from organic compounds | GLAXO WELLCOME, INC. (US) | 1998-11-24 | — | — | US | disclosed |
| EP-0758333-A1 | INTERMEDIATES IN PHARMACEUTICAL CAMPTOTHECIN PREPARATION | GLAXO WELLCOME INC. (US) | 1997-02-19 | — | — | EP | disclosed |
| EP-0758335-A1 | PREPARATION OF A CAMPTOTHECIN DERIVATIVE BY INTRAMOLECULAR CYCLISATION | GLAXO WELLCOME INC. (US) | 1997-02-19 | — | — | EP | disclosed |
| US-5491237-A | Intermediates in pharmaceutical camptothecin preparation | GLAXO WELLCOME INC. (US) | 1996-02-13 | — | — | US | disclosed |
| WO-1995029917-A2 | INTERMEDIATES IN PHARMACEUTICAL CAMPTOTHECIN PREPARATION | GLAXO WELLCOME INC. (US) | 1995-11-09 | — | — | WO | disclosed |
| WO-1995029919-A1 | PREPARATION OF A CAMPTOTHECIN DERIVATIVE BY INTRAMOLECULAR CYCLISATION | GLAXO WELLCOME INC. (US) | 1995-11-09 | — | — | WO | disclosed |