SCHEMBL6436152

SCHEMBL6436152

Clc1ccccc1-c1ccc(-c2ccccc2)cc1

nearest known ligand 0.90

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.90
MAOB P27338 2/20 0.55
CYP1A2 P05177 2/20 0.55
ALDH1A1 P00352 4/20 0.47
HSD11B1 P28845 1/20 0.47
ESR2 Q92731 1/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
HPGD P15428 3/20 0.46
TP53 P04637 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
ALPL P05186 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
NR1H2 P55055 1/20 0.46
NR1H3 Q13133 1/20 0.46
ATM Q13315 1/20 0.46
CSNK2A1 P68400 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23628571 0.95 CYP2A6 (1.00) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
SCHEMBL29355088 0.95 CYP2A6 (1.00) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
SCHEMBL170230 0.95 CYP2A6 (1.00) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
Benzene SCHEMBL28342327 0.95 CYP2A6 (1.00) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
SCHEMBL7124649 0.93 CYP2A6 (0.77) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
Hydrogen Sulfide SCHEMBL9316585 0.92 CYP2A6 (0.94) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
SCHEMBL28800917 0.92 CYP2A6 (0.94) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
Hydrogen Sulfide SCHEMBL9191135 0.92 CYP2A6 (0.94) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
Water SCHEMBL9550934 0.92 CYP2A6 (0.94) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1
SCHEMBL9636468 0.92 CYP2A6 (0.84) CYP2A6MAOBCYP1A2ALDH1A1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1454931-B1 PROPYLENE BLOCK COPOLYMER JAPAN POLYPROPYLENE CORP (JP) 2018-01-24 EP disclosed
US-6916886-B2 Propylene block copolymer JAPAN POLYPROPYLENE CORPORATION (JP) 2005-07-12 US disclosed
US-20050009993-A1 Propylene block copolymer JAPAN POLYPROPYLENE CORPORATION (JP) 2005-01-13 US disclosed
EP-1454931-A1 PROPYLENE BLOCK COPOLYMER Japan Polypropylene Corporation (JP) 2004-09-08 EP disclosed