Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.64 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.64 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.64 |
| ▸ | ITGB8 | P26012 | 5/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.64 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.64 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.64 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436616 | 1.00 | ITGAV (0.64) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6436728 | 0.92 | ITGAV (0.65) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6436730 | 0.92 | ITGAV (0.65) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6436373 | 0.88 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432171 | 0.88 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432004 | 0.88 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432186 | 0.87 | ITGAV (0.84) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432185 | 0.87 | ITGAV (0.84) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL22223395 | 0.86 | ITGAV (0.85) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL22223449 | 0.84 | ITGAV (0.71) | ITGAVITGB3ITGB6ITGB8ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040111-B1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-06-22 | — | — | EP | disclosed |
| US-6017926-A | Integrin receptor antagonists | MERCK & CO., INC. (US) | 2000-01-25 | — | — | US | disclosed |