Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065966 | 0.85 | PTPN1 (0.76) | HDAC8HDAC6PTPN1SMN1; SMN2RAB9A | |
| SCHEMBL3773254 | 0.84 | SLC1A3 (0.58) | PTPN1MEN1KMT2AHPGDPOLB | |
| SCHEMBL4744610 | 0.84 | NPC1 (0.69) | PTPN1SMN1; SMN2RAB9ANPC1MEN1 | |
| Bicarbonate SCHEMBL23420914 | 0.81 | HDAC8 (0.64) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| Bicarbonate SCHEMBL11577277 | 0.81 | HDAC8 (0.64) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14025738 | 0.80 | NPC1 (0.73) | PTPN1SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL17979590 | 0.80 | NPC1 (0.59) | PTPN1SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL17744942 | 0.79 | HDAC6 (0.68) | HDAC8HDAC6RECQLRAB9ATP53 | |
| SCHEMBL10054993 | 0.78 | MEN1 (0.74) | HDAC8HDAC6MEN1KMT2ATDP1 | |
| SCHEMBL19651945 | 0.78 | MEN1 (0.45) | HDAC8HDAC6PTPN1SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | APPLIED RESEARCH SYSTEMS ARS (NL) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | PTPRS, PTPA, PTPMT1 | HDAC8 2841/4885HDAC6 2591/4885PTPN1 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.