Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC5 | O15392 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 13/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6437058 | 1.00 | BIRC5 (0.55) | BIRC5MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL3051653 | 0.88 | BIRC5 (0.49) | BIRC5MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL3051656 | 0.88 | BIRC5 (0.49) | BIRC5MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL8265974 | 0.77 | BIRC5 (0.71) | BIRC5MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL6420773 | 0.74 | BIRC5 (0.57) | BIRC5MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6416003 | 0.73 | MEN1 (0.61) | BIRC5MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6414842 | 0.71 | BIRC5 (1.00) | BIRC5MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL29650064 | 0.71 | BIRC5 (1.00) | BIRC5MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL6414850 | 0.71 | BIRC5 (1.00) | BIRC5MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL8265009 | 0.71 | BIRC5 (0.78) | BIRC5MAPTSMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |
| EP-1529531-A1 | Oxadiazolopyrazine derivatives as pharmaceutically active compounds | 4SC AG (DE) | 2005-05-11 | — | — | EP | disclosed |