Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3682030 | 1.00 | PTGER4 (0.39) | PTGER4PTGER3PTGER2PDK2MEN1 | |
| SCHEMBL1712647 | 0.84 | PDK2 (0.41) | PTGER4PTGER3PTGER2PDK2MEN1 | |
| SCHEMBL14092774 | 0.83 | PTGER4 (0.53) | PTGER4PTGER3PTGER2MEN1POLB | |
| SCHEMBL3429111 | 0.83 | PTGER4 (0.38) | PTGER4PTGER3PTGER2PDK2MEN1 | |
| SCHEMBL6195462 | 0.81 | PTGER4 (0.37) | PTGER4PTGER3PTGER2PDK2MEN1 | |
| SCHEMBL6195464 | 0.81 | PTGER4 (0.37) | PTGER4PTGER3PTGER2PDK2MEN1 | |
| SCHEMBL1712652 | 0.80 | PDK2 (0.39) | PTGER4PTGER3PTGER2PDK2MEN1 | |
| SCHEMBL11624805 | 0.80 | PTGER4 (0.59) | PTGER4PTGER3PTGER2 | |
| SCHEMBL1712920 | 0.79 | PDK2 (0.39) | PTGER4PTGER3PTGER2PDK2MEN1 | |
| SCHEMBL3679883 | 0.78 | PTGER4 (0.41) | PTGER4PTGER3PTGER2PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453503-A4 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK & CO INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1513589-A1 | 1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA INC. (CA) | 2005-03-16 | — | — | EP | disclosed |
| EP-1453503-A2 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | Merck & Co., Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003103772-A1 | 1,5-DISTRIBUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TEATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA & CO. (CA) | 2003-12-18 | — | — | WO | disclosed |
| WO-2003047417-A2 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK & CO., INC. (US) | 2003-06-12 | — | — | WO | disclosed |